This may be a key mechanism for ongoing maintenance and regeneration in vivo …ie within the physical body.
Interesting connection between pluripotent stem cells , telomeres and epigenetic factors which all play roles in healthy longevity and the potential for open lifespan living –
“It is a piece of the puzzle that explains the observed powerful connection between the phenomenon of pluripotency and telomeres -protective structures at the ends of chromosomes- a kind of butterfly effect in which a protein that is only present in telomeres shows a global action on the genome. This butterfly effect is essential to initiate and maintain pluripotency.
The DNA of telomeres directs the production of long RNA molecules called TERRAs. What the CNIO researchers found is that TERRAs act on key genes for pluripotency through the Polycomb proteins, which control the programs that determine the fate of cells in the early embryo by depositing…
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